Clinical Pharmacology has evolved from a discipline dealing with scientific study of medicines in man to medicines for public health. Some of the activities of the discipline outlined by experts include – dealing with biomarkers, pharmacokinetics, drug metabolism, genetics, design and evaluation of clinical trials, drug utilization, clinical guidelines for medicine use, Pharmacovigilance, Pharmacoepidemiology, service support for pharmacotherapy for patient care, experimental medicine of new and old drugs clinical investigation of adverse drug reactions, drug – drug and drug – food interactions, consultation to clinical colleagues, policy makers, regulators, teaching students and practicing doctor, contributing to personalized medicine and public health. In developing countries providing access to affordable, safe, effective medicines especially essential medicines is a priority. Infectious diseases widely prevalent can be eliminated by appropriate use of medicines and vaccines along with appropriate environmental strategy. Non-communicable diseases can be controlled, complications prevented, quality of life improved by rational use of medicines in addition to effecting life style related changes. New drug delivery systems, new uses of drugs, easy to implement treatment schedules for resource poor areas with minimum health care facilities are required. Traditional systems of medicine, herbal drugs, in depth studies of traditional practical use based knowledge passed down generations, combined with modern perspectives of experimental evaluation and standardization will help in making them available for wide spread use with greater confidence in their efficacy and safety.Using Modern methods of teaching along with age-old tradition of handholding and mentoring can motivate professionals trained in clinical pharmacology to contribute further to the wide spectrum and facets of the subject. South Asian countries like India, Nepal, Bhutan, Bangladesh, Sri Lanka, Pakistan provide a great challenge and opportunity for clinical pharmacologist to contribute to health care for improving lives of people. Collaborations across countries, between industries, research institutions and academia can help in fostering Clinical Pharmacology as a discipline and achieve its goals. The South Asian Chapter of American College of Clinical Pharmacology initiative, with the help of many experts and students in South Asian Countries, UK and USA, has grown into a sapling from the seed that was sown in 2006. Launching of the website is an important milestone in its journey. We thank all our mentors collaborators, contributors and students and look forward to developing a strong socially responsive, professional association.